促红细胞生成素对新生儿缺氧缺血性损伤后听觉处理的影响。
The effects of erythropoietin on auditory processing following neonatal hypoxic-ischemic injury.
作者信息
McClure Melissa M, Threlkeld Steven W, Fitch R Holly
机构信息
Department of Psychology, Behavioral Neuroscience Division, Unit 1020, 806 Babbidge Road, Storrs, CT 06069-1020, USA.
出版信息
Brain Res. 2006 May 4;1087(1):190-5. doi: 10.1016/j.brainres.2006.03.016. Epub 2006 Apr 27.
Neonatal hypoxia-ischemia (HI) is a common cause of brain damage and subsequent behavioral deficits in premature/term infants. Rapid auditory processing deficits have been suggested to play a role in later language impairments in this population. We have previously shown auditory deficits in rats with neonatal HI injury and now report novel effects of behavioral sparing and neuroprotection following treatment with a low dose of Erythropoietin using this HI injury model.
新生儿缺氧缺血（HI）是早产/足月儿脑损伤及随后行为缺陷的常见原因。快速听觉处理缺陷被认为在该人群后期的语言障碍中起作用。我们之前已表明新生期HI损伤大鼠存在听觉缺陷，现在使用该HI损伤模型报告低剂量促红细胞生成素治疗后行为改善和神经保护的新作用。
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