Ozgur Senem Konuk, Beyazova Ufuk, Kemaloglu Yusuf Kemal, Maral Isil, Sahin Figen, Camurdan Aysu Duyan, Kizil Yusuf, Dinc Erdem, Tuzun Hakan
Department of Pediatrics, Gazi University Medical Faculty, Ankara, Turkey.
Pediatr Infect Dis J. 2006 May;25(5):401-4. doi: 10.1097/01.inf.0000217370.83948.51.
The objective of this study was to evaluate the effectiveness of inactivated influenza vaccine in preventing acute otitis media (AOM) and otitis media with effusion (OME) in children aged 6 to 60 months who attend day care.
This prospective, single-blind study was conducted in 8 day care centers in Ankara, Turkey. One hundred nineteen (61 vaccinated and 58 unvaccinated against influenza) healthy children were examined at study entry and at 6-week intervals for 6 months by the same 2 otorhinolaryngologists who were blinded about the vaccination status of the children. The frequency of AOM and OME is compared between the 2 groups and the effect of influenza season on frequency of episodes was evaluated. Based on national influenza laboratory data, the influenza season was determined to be the period between December 15, 2003, and January 31, 2004.
The frequencies of AOM, OME and total otitis media episodes in vaccinated children were 2.3%, 22.8% and 25.2%, respectively, and these frequencies were 5.2%, 31.1% and 36.3% in the unvaccinated group. The difference was statistically significant (P < 0.01). This difference was especially prominent in the influenza season (P < 0.05).
Influenza vaccine is effective in reducing AOM and OME episodes in 6- to 60-month-old day care children, especially during influenza season.
本研究的目的是评估灭活流感疫苗对6至60个月大参加日托的儿童预防急性中耳炎（AOM）和中耳积液（OME）的有效性。
这项前瞻性、单盲研究在土耳其安卡拉的8个日托中心进行。119名健康儿童（61名接种流感疫苗，58名未接种流感疫苗）在研究开始时以及6个月内每隔6周由同两名对儿童疫苗接种状况不知情的耳鼻喉科医生进行检查。比较两组中AOM和OME的发生率，并评估流感季节对发作频率的影响。根据国家流感实验室数据，确定流感季节为2003年12月15日至2004年1月31日期间。
接种疫苗儿童中AOM、OME和中耳炎总发作频率分别为2.3%、22.8%和25.2%，未接种疫苗组的这些频率分别为5.2%、31.1%和36.3%。差异具有统计学意义（P < 0.01）。这种差异在流感季节尤为显著（P < 0.05）。
流感疫苗对减少6至60个月大日托儿童的AOM和OME发作有效，尤其是在流感季节。
