Rosenthal G A, Gulati D K, Sabharwal P S
T. H. Morgan School of Biological Sciences, University of Kentucky, Lexington, Kentucky 40506.
Plant Physiol. 1975 Sep;56(3):420-4. doi: 10.1104/pp.56.3.420.
The aquatic microphyte, Lemna minor L., was utilized to assess the relative toxicity and general growth effects of canavanine, canaline, ureidohomoserine (UHS), and canavaninosuccinate (CSA). These amino acids are constituents of the canaline-urea cycle and structural analogues of the ornithine-urea cycle amino acids.Comparative growth studies with L. minor revealed that the canaline-urea cycle amino acids are potent antimetabolites. With the exception of CSA, they are extremely toxic at a concentration of 5 mum. Over a concentration range of 1 to 4 mum, canavanine is the most growth-inhibiting of the canaline-urea cycle amino acids. At or above 5 mum, canavanine and canaline possess comparable toxicity. UHS is less growth-inhibiting than canavanine or canaline, and CSA is the least toxic of the canaline-urea cycle intermediates.
水生微植物小浮萍(Lemna minor L.)被用于评估刀豆氨酸、刀豆碱、脲基高丝氨酸(UHS)和刀豆氨琥珀酸(CSA)的相对毒性及对生长的总体影响。这些氨基酸是刀豆碱 - 尿素循环的组成成分,也是鸟氨酸 - 尿素循环氨基酸的结构类似物。对小浮萍进行的比较生长研究表明,刀豆碱 - 尿素循环氨基酸是强效抗代谢物。除CSA外,它们在浓度为5微摩尔时具有极高毒性。在1至4微摩尔的浓度范围内,刀豆氨酸是刀豆碱 - 尿素循环氨基酸中对生长抑制作用最强的。在5微摩尔及以上浓度时,刀豆氨酸和刀豆碱具有相当的毒性。UHS对生长的抑制作用小于刀豆氨酸或刀豆碱,而CSA是刀豆碱 - 尿素循环中间产物中毒性最小的。