Moody K D, Percy D H, Papero M A, Morgenstern S E
Section of Comparative Medicine, Yale School of Medicine, New Haven, CT.
Lab Anim Sci. 1991 Oct;41(5):427-31.
Endometriosis was diagnosed in an aged dysmenorrheic rhesus monkey (Macaca mulatta) after biopsy of a 7 cm abdominal mass which could not be completely resected due to extensive adhesions. A 6-month course of treatment with leuprolide, a gonadotropin-releasing hormone agonist, resulted in cessation of menstrual cycles and marked clinical improvement. Dysmenorrhea and hypovolemic shock occurred 2 months after therapy was completed. Despite supportive treatment and resumption of leuprolide, the primate's clinical deterioration and abdominal mass enlargement necessitated euthanasia. To our knowledge, this is the first report of a case of endometriosis in a rhesus macaque treated with a gonadotropin-releasing hormone agonist. Although prolonged leuprolide therapy was clinically effective, its cost and the difficulty in early diagnosis of endometriosis may limit its use in nonhuman primate medicine.
在对一只患有痛经的老年恒河猴（猕猴）进行活检后，诊断出子宫内膜异位症。该猴腹部有一个7厘米的肿块，由于广泛粘连无法完全切除。使用促性腺激素释放激素激动剂亮丙瑞林进行为期6个月的治疗，导致月经周期停止，临床症状明显改善。治疗结束2个月后出现痛经和低血容量性休克。尽管进行了支持治疗并恢复使用亮丙瑞林，但该灵长类动物的临床状况恶化，腹部肿块增大，最终不得不实施安乐死。据我们所知，这是首例用促性腺激素释放激素激动剂治疗的恒河猴子宫内膜异位症病例报告。尽管亮丙瑞林长期治疗在临床上有效，但其成本以及子宫内膜异位症早期诊断的困难可能会限制其在非人灵长类医学中的应用。
