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1
Inhibition of beta-1,4-Glucan Biosynthesis by Deoxyglucose : The Effect on the Glucosylation of Lipid Intermediates.脱氧葡萄糖对β-1,4-葡聚糖生物合成的抑制作用：对脂质中间物糖基化的影响。
Plant Physiol. 1983 Jan;71(1):76-81. doi: 10.1104/pp.71.1.76.
2
Formation of 2-deoxyglucose-containing lipid-linked oligosaccharides. Interference with glycosylation of glycoproteins.含2-脱氧葡萄糖的脂连接寡糖的形成。对糖蛋白糖基化的干扰。
Eur J Biochem. 1978 Oct 16;90(3):505-16. doi: 10.1111/j.1432-1033.1978.tb12630.x.
3
Fluoroglucose-inhibition of protein glycosylation in vivo. Inhibition of mannose and glucose incorporation into lipid-linked oligosaccharides.体内氟葡萄糖对蛋白质糖基化的抑制作用。对甘露糖和葡萄糖掺入脂质连接寡糖的抑制作用。
Eur J Biochem. 1980 Aug;109(2):331-41. doi: 10.1111/j.1432-1033.1980.tb04799.x.
4
Mannosyltransferase activity in calf pancreas microsomes. Formation of 14C-labeled lipid-linked oligosaccharides from GDP-D-[14C]mannose and pancreatic dolichyl beta-D-[14C]mannopyranosyl phosphate.小牛胰腺微粒体中的甘露糖基转移酶活性。由GDP-D-[14C]甘露糖和胰腺多萜醇β-D-[14C]甘露吡喃糖基磷酸形成14C标记的脂连接寡糖。
J Biol Chem. 1977 Jan 10;252(1):224-34.
5
The dolichol pathway of protein glycosylation in rat liver. Stimulation by GTP of the incorporation of N-acetylglucosamine in endogenous lipids and proteins of rough microsomes treated with pyrophosphate.大鼠肝脏中蛋白质糖基化的多萜醇途径。焦磷酸处理的糙面微粒体内源性脂质和蛋白质中N-乙酰葡糖胺掺入受GTP的刺激。
Eur J Biochem. 1979 May 2;96(1):17-26. doi: 10.1111/j.1432-1033.1979.tb13008.x.
6
Dolichol pathway in lymphocytes from rat spleen. Influence of the glucosylation on the cleavage of dolichyl diphosphate oligosaccharides into phosphooligosaccharides.大鼠脾脏淋巴细胞中的多萜醇途径。糖基化对二磷酸多萜醇寡糖裂解为磷酸寡糖的影响。
Eur J Biochem. 1981 Jul;117(2):285-90. doi: 10.1111/j.1432-1033.1981.tb06335.x.
7
Control of N-linked oligosaccharide synthesis: cellular levels of dolichyl phosphate are not the only regulatory factor.N-连接寡糖合成的调控：磷酸多萜醇的细胞水平并非唯一的调控因子。
Biochemistry. 1990 Sep 4;29(35):8077-84. doi: 10.1021/bi00487a013.
8
Biosynthesis of lipid-linked oligosaccharides in embryonic liver. Glucosylation of mannose containing dolichyl diphosphate oligosaccharide.胚胎肝脏中脂连接寡糖的生物合成。含多萜醇二磷酸寡糖的甘露糖的糖基化作用。
Int J Biochem. 1986;18(2):195-8. doi: 10.1016/0020-711x(86)90157-6.
9
Rat liver microsomes catalyse mannosyl transfer from GDP-D-mannose to retinyl phosphate with high efficiency in the absence of detergents.在没有去污剂的情况下，大鼠肝脏微粒体能够高效催化从GDP-D-甘露糖到磷酸视黄酯的甘露糖基转移反应。
Biochem J. 1981 Dec 15;200(3):529-38. doi: 10.1042/bj2000529.
10
Metabolism of lipid-linked oligosaccharide intermediates in rat spleen lymphocytes. Evidence for ectoglycosyltransferase activities.大鼠脾淋巴细胞中脂连接寡糖中间体的代谢。外糖基转移酶活性的证据。
Eur J Biochem. 1980 Nov;112(1):81-6. doi: 10.1111/j.1432-1033.1980.tb04989.x.

引用本文的文献

1
β-Glucan biosynthesis in synchronous cells of Prototheca zopfii.小体藻类毕赤酵母同步细胞中的β-葡聚糖生物合成。
Planta. 1985 Aug;165(3):348-53. doi: 10.1007/BF00392231.
2
Tetracyclines, verapamil and nifedipine induce callose deposition at specific cell sites in Riella helicophylla.四环类、维拉帕米和硝苯地平在 Riella helicophylla 特定细胞部位诱导胼胝质沉积。
Planta. 1986 Dec;169(4):546-54. doi: 10.1007/BF00392105.
3
Effects of tissue-preparation-induced callose synthesis on estimates of plasmodesma size exclusion limits.组织制备诱导的胼胝质合成对胞间连丝大小排阻极限估计的影响。
Protoplasma. 2001;216(1-2):47-55. doi: 10.1007/BF02680130.
4
Inhibitors of protein glycosylation and glycoprotein processing in viral systems.病毒系统中蛋白质糖基化和糖蛋白加工的抑制剂。
Pharmacol Ther. 1987;33(2-3):221-86. doi: 10.1016/0163-7258(87)90066-0.

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Biosynthesis of dolichyl phosphate: characterization and site of synthesis in algae.磷酸多萜醇的生物合成：藻类中的特性及合成位点
Plant Physiol. 1978 Feb;61(2):248-51. doi: 10.1104/pp.61.2.248.
2
METABOLIC STUDIES WITH 2-DEOXYHEXOSES. I. MECHANISMS OF INHIBITION OF GROWTH AND FERMENTATION IN BAKER'S YEAST.2-脱氧己糖的代谢研究。I. 对面包酵母生长和发酵的抑制机制。
Biochim Biophys Acta. 1964 May 11;86:216-23. doi: 10.1016/0304-4165(64)90045-5.
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Dolichol-dependent protein glycosylation in a deoxy-glucose-resistant baby-hamster-kidney cell line.
Biochim Biophys Acta. 1980 Aug 13;631(2):386-91. doi: 10.1016/0304-4165(80)90312-8.
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Deoxyglucose inhibition of protein glycosylation: effects of nucleotide deoxysugars on the formation of glucosylated lipid intermediates.
Arch Biochem Biophys. 1981 Jan;206(1):65-71. doi: 10.1016/0003-9861(81)90066-7.
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The structure of the Aerobacter aerogenes A3(S1) polysaccharide. I. A reexamination using improved procedures for methylation analysis.产气气杆菌A3(S1)多糖的结构。I. 使用改进的甲基化分析程序进行的重新研究。
Biochemistry. 1966 May;5(5):1508-17. doi: 10.1021/bi00869a009.
6
The formation of uridine diphosphate-2-deoxy-D-glucose in yeast.酵母中尿苷二磷酸 - 2 - 脱氧 - D - 葡萄糖的形成。
Biochim Biophys Acta. 1966 May 26;121(1):213-4. doi: 10.1016/0304-4165(66)90379-5.
7
The formation of guanosine diphosphate-2-deoxy-D-glucose in yeast.酵母中鸟苷二磷酸 -2- 脱氧 -D- 葡萄糖的形成。
Biochim Biophys Acta. 1968 Mar 11;156(2):432-4. doi: 10.1016/0304-4165(68)90281-x.
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Isolation, purification, and properties of the lipid-linked intermediates of O-antigen biosynthesis.O抗原生物合成中脂连接中间体的分离、纯化及性质
Arch Biochem Biophys. 1966 Sep 26;116(1):425-35. doi: 10.1016/0003-9861(66)90049-x.
9
The proteolytic enzymes of the K-1 strain of Streptomyces griseus obtained from a commercial preparation (Pronase). II. The activity of a serine enzyme in 6 M guanidinium chloride.从市售制剂（链霉蛋白酶）中获得的灰色链霉菌K-1菌株的蛋白水解酶。II. 丝氨酸酶在6M氯化胍中的活性。
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10
Nucleoside-diphosphate derivatives of 2-deoxy-D-glucose in animal cells.动物细胞中2-脱氧-D-葡萄糖的核苷二磷酸衍生物
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脱氧葡萄糖对β-1,4-葡聚糖生物合成的抑制作用：对脂质中间物糖基化的影响。

Inhibition of beta-1,4-Glucan Biosynthesis by Deoxyglucose : The Effect on the Glucosylation of Lipid Intermediates.

机构信息

Institüt fur Virologie, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Giessen, D-6300 Giessen, Federal Republic of Germany.

出版信息

Plant Physiol. 1983 Jan;71(1):76-81. doi: 10.1104/pp.71.1.76.

DOI:10.1104/pp.71.1.76
PMID:16662803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1065989/
Abstract

GDP- and UDP-deoxyglucose inhibit the incorporation of glucose from UDP-glucose into dolichyl phosphate glucose and dolichyl pyrophosphate oligosaccharides. GDP-deoxyglucose inhibits by competing with the physiological nucleotide sugars for dolichyl phosphate, and dolichyl phosphate deoxyglucose is formed. This inhibition is reversed by excess of dolichyl phosphate. UDP-deoxyglucose does not give rise to a lipid-linked derivative, and inhibition by this analog is not reversed by dolichyl phosphate. The UDP- and GDP-derivatives of deoxyglucose inhibit the incorporation of glucose into glucose-containing glycoproteins. This effect seems to be the result of the inhibition of lipid intermediates glucosylation and is comparable to the effect produced by coumarin. Cellulose synthetase activity is not affected by UDP- or GDP-deoxyglucose. On the other hand, deoxyglucose inhibits the formation of beta-1,4-glucans in vivo.

摘要

GDP- 和 UDP-脱氧葡萄糖抑制从 UDP-葡萄糖掺入到磷酸多萜醇葡萄糖和磷酸多萜醇焦磷酸寡糖中的葡萄糖。GDP-脱氧葡萄糖通过与生理核苷酸糖竞争磷酸多萜醇而抑制，形成磷酸多萜醇脱氧葡萄糖。这种抑制可以通过过量的磷酸多萜醇逆转。UDP-脱氧葡萄糖不会产生脂联衍生物，并且这种类似物的抑制不能通过磷酸多萜醇逆转。脱氧葡萄糖的 UDP-和 GDP-衍生物抑制葡萄糖掺入含有葡萄糖的糖蛋白中。这种作用似乎是脂质中间体糖基化抑制的结果，与香豆素产生的作用相当。纤维素合成酶活性不受 UDP-或 GDP-脱氧葡萄糖的影响。另一方面，脱氧葡萄糖抑制体内β-1,4-葡聚糖的形成。