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2

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3

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4

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5

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6

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7

The formation of guanosine diphosphate-2-deoxy-D-glucose in yeast.

Biochim Biophys Acta. 1968 Mar 11;156(2):432-4. doi: 10.1016/0304-4165(68)90281-x.

8

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9

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10

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脱氧葡萄糖对β-1,4-葡聚糖生物合成的抑制作用：对脂质中间物糖基化的影响。

Inhibition of beta-1,4-Glucan Biosynthesis by Deoxyglucose : The Effect on the Glucosylation of Lipid Intermediates.

机构信息

Institüt fur Virologie, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Giessen, D-6300 Giessen, Federal Republic of Germany.

出版信息

Plant Physiol. 1983 Jan;71(1):76-81. doi: 10.1104/pp.71.1.76.

DOI:10.1104/pp.71.1.76

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1065989/

Abstract

GDP- and UDP-deoxyglucose inhibit the incorporation of glucose from UDP-glucose into dolichyl phosphate glucose and dolichyl pyrophosphate oligosaccharides. GDP-deoxyglucose inhibits by competing with the physiological nucleotide sugars for dolichyl phosphate, and dolichyl phosphate deoxyglucose is formed. This inhibition is reversed by excess of dolichyl phosphate. UDP-deoxyglucose does not give rise to a lipid-linked derivative, and inhibition by this analog is not reversed by dolichyl phosphate. The UDP- and GDP-derivatives of deoxyglucose inhibit the incorporation of glucose into glucose-containing glycoproteins. This effect seems to be the result of the inhibition of lipid intermediates glucosylation and is comparable to the effect produced by coumarin. Cellulose synthetase activity is not affected by UDP- or GDP-deoxyglucose. On the other hand, deoxyglucose inhibits the formation of beta-1,4-glucans in vivo.

摘要

GDP- 和 UDP-脱氧葡萄糖抑制从 UDP-葡萄糖掺入到磷酸多萜醇葡萄糖和磷酸多萜醇焦磷酸寡糖中的葡萄糖。GDP-脱氧葡萄糖通过与生理核苷酸糖竞争磷酸多萜醇而抑制，形成磷酸多萜醇脱氧葡萄糖。这种抑制可以通过过量的磷酸多萜醇逆转。UDP-脱氧葡萄糖不会产生脂联衍生物，并且这种类似物的抑制不能通过磷酸多萜醇逆转。脱氧葡萄糖的 UDP-和 GDP-衍生物抑制葡萄糖掺入含有葡萄糖的糖蛋白中。这种作用似乎是脂质中间体糖基化抑制的结果，与香豆素产生的作用相当。纤维素合成酶活性不受 UDP-或 GDP-脱氧葡萄糖的影响。另一方面，脱氧葡萄糖抑制体内β-1,4-葡聚糖的形成。