乙醇和DSIP对突触体小泡中36Cl通量的影响。
Effect of ethanol and DSIP on the 36Cl-flux in synaptosomal vesicles.
作者信息
Yukhananov R, Rebrov I, Tennila T, Maisky A
机构信息
Institute of Pharmacology, Academy of Medical Sciences, Moscow, USSR.
出版信息
Mol Chem Neuropathol. 1991 Dec;15(3):235-48. doi: 10.1007/BF03161062.
Delta-sleep-inducing peptide (DSIP) is an endogenous substance that regulates the response of the organism to stress. It was found that DSIP, like diazepam and ethanol, activates muscimol-stimulated 36Cl- uptake in the rat brain cortex and partially counteracts the stimulatory action of ethanol on this process. The effect of peptide disappears at the lowering of the incubation temperature. We propose that DSIP is a concordant regulator partly mediating its action through the membrane phospholipids.
δ-睡眠诱导肽（DSIP）是一种调节机体对应激反应的内源性物质。研究发现，DSIP与地西泮和乙醇一样，可激活大鼠大脑皮层中由蝇蕈醇刺激的³⁶Cl⁻摄取，并部分抵消乙醇对该过程的刺激作用。当孵育温度降低时，该肽的作用消失。我们认为，DSIP是一种协同调节剂，部分通过膜磷脂介导其作用。
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