沙奎那韦对伊马替尼耐药慢性粒细胞白血病细胞系的影响。
The effects of saquinavir on imatinib-resistant chronic myelogenous leukemia cell lines.
作者信息
Timeus Fabio, Crescenzio Nicoletta, Ricotti Emanuela, Doria Alessandra, Bertin Daniele, Saglio Giuseppe, Tovo Pier Angelo
出版信息
Haematologica. 2006 May;91(5):711-2.
PMID:16670078
Abstract
We evaluated the effect of the human immunodeficiency virus (HIV) protease inhibitor saquinavir on the imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia cell lines. Saquinavir, which is also a proteasome blocker, showed dose- and time-related anti-proliferative activity, particularly on the imatinib-resistant lines and a pro-apoptotic effect. Association with imatinib caused a significant increase of activity.
摘要
我们评估了人类免疫缺陷病毒（HIV）蛋白酶抑制剂沙奎那韦对伊马替尼敏感和伊马替尼耐药的慢性粒细胞白血病细胞系的作用。沙奎那韦也是一种蛋白酶体阻滞剂，显示出剂量和时间相关的抗增殖活性，特别是对伊马替尼耐药细胞系，并有促凋亡作用。与伊马替尼联合使用可显著提高活性。
Zotero 插件