Palladium-catalyzed synthesis of 2-(aminomethyl)indoles from ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonate.
作者信息
Ambrogio Ilaria, Cacchi Sandro, Fabrizi Giancarlo
机构信息
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi La Sapienza, Roma, Italy.
出版信息
Org Lett. 2006 May 11;8(10):2083-6. doi: 10.1021/ol060499n.
PMID:16671787
Abstract
[reaction: see text] The palladium-catalyzed reaction of ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonate with piperazines in the presence of Pd(PPh(3))(4) in THF at 80 degrees C affords 2-(piperazin-1-ylmethyl)indoles in excellent yields. Good to excellent yields are also obtained with other secondary amines.
摘要
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