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2型糖尿病非裔美国人3年期间抑郁症状和代谢控制的变化。

Changes in depressive symptoms and metabolic control over 3 years among African Americans with type 2 diabetes.

作者信息

Gary Tiffany L, Baptiste-Roberts Kesha, Crum Rosa M, Cooper Lisa A, Ford Daniel E, Brancati Frederick L

机构信息

The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

出版信息

Int J Psychiatry Med. 2005;35(4):377-82. doi: 10.2190/BQ22-4HU0-P6EK-L7YX.

Abstract

OBJECTIVE

It is established that individuals with diabetes have high rates of depression, but the longitudinal relationship between depression and glycemic control has not been well examined, particularly among African Americans. The objective of this study was to evaluate the longitudinal relationship between depressive symptoms and metabolic control.

METHOD

We conducted an earlier cross-sectional study that demonstrated marginal and significant associations between depressive symptoms (using the Center for Epidemiologic Studies Depression Scale [CES-D]) and metabolic control (HbA1c, lipids, blood pressure) among 183 African Americans with type 2 diabetes. In this report, we present data on these individuals, followed for three years, and examine the relationship between change in depressive symptoms and change in metabolic control over that time period.

RESULTS

Results showed that that there were no statistically significant associations between baseline or change in depressive symptoms and metabolic control over three years. Limited statistical power may explain this negative finding.

CONCLUSIONS

This study provides insight into the relationship between depression and metabolic control. Prospective observational studies are needed to further evaluate this relationship.

摘要

目的

已证实糖尿病患者的抑郁症发病率很高,但抑郁症与血糖控制之间的纵向关系尚未得到充分研究,尤其是在非裔美国人中。本研究的目的是评估抑郁症状与代谢控制之间的纵向关系。

方法

我们之前进行了一项横断面研究,该研究表明,在183名患有2型糖尿病的非裔美国人中,抑郁症状(使用流行病学研究中心抑郁量表[CES-D])与代谢控制(糖化血红蛋白、血脂、血压)之间存在边缘性和显著相关性。在本报告中,我们展示了对这些个体进行三年随访的数据,并研究了该时间段内抑郁症状变化与代谢控制变化之间的关系。

结果

结果显示,抑郁症状基线水平或其变化与三年间的代谢控制之间不存在统计学上的显著关联。统计效力有限可能解释了这一阴性结果。

结论

本研究为抑郁症与代谢控制之间的关系提供了见解。需要进行前瞻性观察研究以进一步评估这种关系。

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