尾型转录因子-2在胃癌发生不同阶段胃黏膜中的表达及意义
[Expression and significance of caudal type transcription factor-2 in gastric mucosa at different stages of gastric carcinogenesis].
作者信息
Chen Hui-xin, Chen Min-hu, Song Xin
机构信息
Department of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2006 Jan 24;86(4):247-9.
OBJECTIVE
To investigate the expression and significance of caudal type transcription factor-2 (Cdx2) in gastric mucosa at different stages of carcinogenesis.
METHODS
By using ABC immunohistochemistry, the expression of Cdx2 was detected in the biopsy specimens of 104 cases of chronic superficial gastritis, 98 cases of chronic atrophic gastritis, 112 cases of intestinal metaplasia, 106 cases of dysplasia and 97 cases of intestinal-type gastric carcinoma.
RESULTS
Cdx2 was expressed in the specimens of intestinal metaplasia with an expression rate of 86.6% (97/112), significantly higher than those in dysplasia (58.5%, 62/106) and intestinal-type gastric carcinoma (56.9%, 53/93) (both P < 0.01), while was not expressed in the specimens of chronic superficial gastritis and chronic atrophic gastritis. No significant difference was found between the expression rate of Cdx2 was between the specimens of dysplasia and those of intestinal-type gastric carcinoma (P > 0.05).
CONCLUSION
Cdx2 may be a novel marker of intestinal metaplasia and may play an important role in the carcinogenesis of the intestinal-type gastric carcinoma.
目的
探讨尾型转录因子2（Cdx2）在胃癌发生不同阶段胃黏膜中的表达及意义。
方法
采用ABC免疫组化法检测104例慢性浅表性胃炎、98例慢性萎缩性胃炎、112例肠化生、106例异型增生及97例肠型胃癌活检标本中Cdx2的表达。
结果
Cdx2在肠化生标本中表达，表达率为86.6%（97/112），显著高于异型增生（58.5%，62/106）和肠型胃癌（56.9%，53/93）（均P<0.01），而在慢性浅表性胃炎和慢性萎缩性胃炎标本中不表达。Cdx2在异型增生标本与肠型胃癌标本中的表达率差异无统计学意义（P>0.05）。
结论
Cdx2可能是肠化生的新型标志物，可能在肠型胃癌的发生中起重要作用。
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