妊娠期的痣与黑色素瘤。

Nevi and melanoma in pregnancy.

作者信息

Driscoll Marcia S, Grant-Kels Jane M

机构信息

Department of Dermatology, University of Connecticut Health Center, Farmington, CT 06030, USA.

出版信息

Dermatol Clin. 2006 Apr;24(2):199-204, vi. doi: 10.1016/j.det.2006.01.003.

DOI:10.1016/j.det.2006.01.003

PMID:16677966

Abstract

The influence of pregnancy on melanocytic nevi and malignant melanoma (MM) continues to be a controversial issue. Over the past 50 years, case reports and uncontrolled studies have suggested that nevi are more likely to become malignant during pregnancy, and MM diagnosed during pregnancy has a poor prognosis. Clinical and laboratory observations suggested that pregnancy-associated hormones may influence nevi and MM. Recent clinical and laboratory evidence suggests, however, that pregnancy does not influence the prognosis of MM, nor does it seem to cause significant changes in nevi. A clear link between hormones and MM has not been established. An analysis of this evidence is presented along with practical recommendations for the patient.

摘要

妊娠对黑素细胞痣和恶性黑色素瘤（MM）的影响一直是个有争议的问题。在过去50年里，病例报告和非对照研究表明，痣在妊娠期间更有可能恶变，妊娠期间诊断出的MM预后较差。临床和实验室观察表明，与妊娠相关的激素可能会影响痣和MM。然而，最近的临床和实验室证据表明，妊娠并不影响MM的预后，似乎也不会导致痣发生显著变化。激素与MM之间尚未建立明确的联系。本文对这些证据进行了分析，并为患者提供了实用建议。