Bharadwaj Rajnish, Kolodkin Alex L
Howard Hughes Medical Institute, The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 N. Wolfe St./1001 PCTB, Baltimore, MD 21205, USA.
Cell. 2006 May 5;125(3):421-4. doi: 10.1016/j.cell.2006.04.012.
Neuronal processes exhibit exquisitely complex branching patterns crucial for the formation of distinct neural circuits. In this issue of Cell, Chen et al. (2006) show that the isoform diversity of the Dscam protein in Drosophila is required to establish stereotypical axonal branching patterns, suggesting that nonrandom expression of Dscam alternative splice variants determines neural connectivity.
神经元突起呈现出极其复杂的分支模式，这对于形成独特的神经回路至关重要。在本期《细胞》杂志中，陈等人（2006年）表明，果蝇中Dscam蛋白的亚型多样性对于建立定型的轴突分支模式是必需的，这表明Dscam可变剪接变体的非随机表达决定了神经连接性。
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