Martín Dávila F, Delgado Portela M, Furio V, Casanueva T, Ruiz Marcillán C, Urzay G, Puig A
Servicio de Anatomía Patológica del Hospital Nuestra Señora del Carmen, Madrid, España.
Arch Esp Urol. 1991 Dec;44(10):1153-6.
We report an additional case of small cell carcinoma of the bladder with oat cell features in a 67-year-old male patient. This tumor, recently described at this site, has clinico-pathological features that make it distinct from other bladder tumors. Histologically, it closely resembles its pulmonary counterpart with positive results for epithelial markers and neuroendocrine differentiation. The latter has been confirmed by the observation of the typical neurosecretory granules at ultrastructural level. It generally presents in the elderly male patients. It is extremely aggressive and responds poorly to the commonly used treatment. The histogenesis of this rare tumor of the bladder has, as yet, not been elucidated. The different hypotheses that have been put forward are discussed.
我们报告了一例67岁男性膀胱小细胞癌伴燕麦细胞特征的病例。这种最近在该部位被描述的肿瘤,具有使其与其他膀胱肿瘤不同的临床病理特征。组织学上,它与肺部的同类肿瘤非常相似,上皮标记物和神经内分泌分化呈阳性。后者已通过超微结构水平观察到典型的神经分泌颗粒得到证实。它通常发生在老年男性患者中。它极具侵袭性,对常用治疗反应不佳。这种罕见的膀胱肿瘤的组织发生学尚未阐明。本文讨论了已提出的不同假说。