Nelson Stephen C, Hennessy Jane M, McDonough Elizabeth A, Guck Kelli L
Children's Hospitals and Clinics of Minnesota, Minneapolis, MN, USA.
J Pediatr Hematol Oncol. 2006 Mar;28(3):182-5. doi: 10.1097/01.mph.0000210063.80828.f0.
Iron overload can be a major complication in children requiring chronic red cell transfusions. Compliance with subcutaneous deferoxamine is often poor. We report the use of very high-dose deferoxamine in 14 children. Patients received intravenous deferoxamine at 15 mg/kg/h over 48 hours every 2 or 4 weeks. The mean duration of treatment was 18 months. Therapy was well tolerated and our regimen was successful in removing excess iron. Intermittent very high-dose intravenous deferoxamine is practical, safe, and effective in managing iron overload in children. Treatment can be given as an outpatient without a central venous catheter.
铁过载可能是需要长期红细胞输血的儿童的主要并发症。皮下注射去铁胺的依从性通常较差。我们报告了14例儿童使用超高剂量去铁胺的情况。患者每2或4周接受一次静脉注射去铁胺，剂量为15 mg/kg/h，持续48小时。平均治疗时间为18个月。治疗耐受性良好，我们的治疗方案成功地清除了过量的铁。间歇性超高剂量静脉注射去铁胺在治疗儿童铁过载方面切实可行、安全有效。治疗可以在门诊进行，无需中心静脉导管。
