帕金森病中的线粒体：在遗传学的些许帮助下再度流行起来。
Mitochondria in Parkinson disease: back in fashion with a little help from genetics.
作者信息
Muqit Miratul M K, Gandhi Sonia, Wood Nicholas W
机构信息
Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, England.
出版信息
Arch Neurol. 2006 May;63(5):649-54. doi: 10.1001/archneur.63.5.649.
PMID:16682534
Abstract
Parkinson disease is a devastating neurodegenerative disorder with no known cure. Impairment in mitochondrial dysfunction is thought to play a major role in the pathogenesis. Recent genetic advances suggest that mitochondrial dysfunction may be the primary defect. Drugs that target the mitochondria may therefore represent the best hope for disease-modifying therapies in Parkinson disease.
摘要
帕金森病是一种毁灭性的神经退行性疾病，目前尚无已知的治愈方法。线粒体功能障碍被认为在发病机制中起主要作用。最近的遗传学进展表明，线粒体功能障碍可能是主要缺陷。因此，针对线粒体的药物可能是帕金森病疾病修饰疗法的最大希望。
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