皮质类固醇会损害大脑吗？

Do corticosteroids damage the brain?

作者信息

Herbert J, Goodyer I M, Grossman A B, Hastings M H, de Kloet E R, Lightman S L, Lupien S J, Roozendaal B, Seckl J R

机构信息

Department of Physiology, Development and Neuroscience, and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK.

出版信息

J Neuroendocrinol. 2006 Jun;18(6):393-411. doi: 10.1111/j.1365-2826.2006.01429.x.

DOI:10.1111/j.1365-2826.2006.01429.x

PMID:16684130

Abstract

Corticosteroids are an essential component of the body's homeostatic system. In common with other such systems, this implies that corticosteroid levels in blood and, more importantly, in the tissues remain within an optimal range. It also implies that this range may vary according to circumstance. Lack of corticosteroids, such as untreated Addison's disease, can be fatal in humans. In this review, we are principally concerned with excess or disturbed patterns of circulating corticosteroids in the longer or shorter term, and the effects they have on the brain.

摘要

皮质类固醇是人体稳态系统的重要组成部分。与其他此类系统一样，这意味着血液中，更重要的是组织中的皮质类固醇水平保持在最佳范围内。这也意味着该范围可能因情况而异。缺乏皮质类固醇，如未经治疗的艾迪生病，对人类可能是致命的。在本综述中，我们主要关注循环皮质类固醇在短期或长期内的过量或紊乱模式，以及它们对大脑的影响。