Albertin Giovanna, Casale Valentina, Ziolkowska Agnieszka, Spinazzi Raffaella, Malendowicz Ludwik K, Rossi Gian Paolo, Nussdorfer Gastone G
Department of Human Anatomy and Physiology, Section of Anatomy, School of Medicine, University of Padua, Italy.
Int J Mol Med. 2006 Jun;17(6):1111-5.
Urotensin-II (UII) is a potent hypertensive peptide, which has been recognized as an endogenous ligand of the G protein-coupled receptor (GPR)-14, now named UT-R. Real-time PCR demonstrated the expression of UII and UT-R mRNAs in both dispersed and in vitro cultured rat adrenocortical cells. UII concentration-dependently decreased basal, but not ACTH-stimulated, corticosterone secretion from cultured adrenocortical cells, and the effect was abolished by the UT-R antagonist Palosuran. UII did not affect the proliferation rate of cultured cells. Taken together, these findings suggest that UII may be included in the group of peptides (adrenomedullin, atrial natriuretic peptide, neurotensin and beacon), that, acting in an autocrine-paracrine manner, are involved in the inhibitory tuning of adrenocortical secretion.
尾加压素II（UII）是一种强效的高血压肽，它已被确认为G蛋白偶联受体（GPR）-14（现称为UT-R）的内源性配体。实时聚合酶链反应显示，UII和UT-R信使核糖核酸在分散的和体外培养的大鼠肾上腺皮质细胞中均有表达。UII浓度依赖性地降低了培养的肾上腺皮质细胞基础状态下（而非促肾上腺皮质激素刺激下）的皮质酮分泌，且UT-R拮抗剂帕罗西汀可消除该效应。UII不影响培养细胞的增殖率。综上所述，这些发现提示，UII可能属于肽类（肾上腺髓质素、心房利钠肽、神经降压素和比考诺肽）的范畴，它们以自分泌-旁分泌方式发挥作用，参与肾上腺皮质分泌的抑制性调节。
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