基因组学对发现抗传染病药物的影响。

The impact of genomics on discovering drugs against infectious diseases.

作者信息

Boshoff Helena I M, Manjunatha Ujjini H

机构信息

National Institutes of Health, Tuberculosis Research Section, LIG/NIAID/NIH, Twinbrook II, Room 239, 12441 Parklawn Drive, Rockville, MD 20852, USA.

出版信息

Microbes Infect. 2006 May;8(6):1654-61. doi: 10.1016/j.micinf.2005.11.018. Epub 2006 Jan 26.

DOI:10.1016/j.micinf.2005.11.018

PMID:16690340

Abstract

Genomics is accelerating the progress in data generation and interpretation in the global analyses of components of cells, including the spectrum of lipids, RNA, metabolites, proteins, mutational phenotypes or DNA methylation sites. Integration of the knowledge generated by these diverse strategies is predicted to have a tremendous impact on approaches to rational drug discovery against infectious diseases.

摘要

基因组学正在加速全球细胞成分分析中数据生成和解读的进展，这些细胞成分包括脂质、RNA、代谢物、蛋白质、突变表型或DNA甲基化位点的谱。预计通过这些不同策略所产生的知识整合，将对针对传染病的合理药物发现方法产生巨大影响。