Tan Juan, Li Jiawen, Chen Shanjuan, Wu Yan, Qin Fang T, Ding Juan, Cao Fei, Zhang Shaoru
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
J Huazhong Univ Sci Technolog Med Sci. 2005;25(6):744-6. doi: 10.1007/BF02896190.
In order to study the susceptibility of murine vaginal mucosa to Candida albicans under different conditions, vaginal lavage fluid and vaginal tissue of mice were observed and compared between murine models with normal immune system (estrogen-treated mice) and immunosuppressed murine model, and between primary infection model of vaginal candidiasis and secondary infection one. The average level of colony forming unit (CFU) from the immuosuppressed group was higher than that from estrogen-treated group at each time point and the peak time was delayed. The differences between the two groups were statistically significant (P < 0.05) from the fourth day after inoculation. A significant difference existed in the average level of CFU between the control group and the estrogen-treated group (P < 0.05), and between the control group and the immuosuppressed group (P < 0.01). It was concluded that the vaginal mucosa from the immunosuppressed mice is more susceptible to Candida albicans and no difference is found in susceptibility between mice with primary infection and secondary infection.
为研究不同条件下小鼠阴道黏膜对白色念珠菌的易感性，对正常免疫系统小鼠模型（雌激素处理小鼠）和免疫抑制小鼠模型之间，以及阴道念珠菌病原发性感染模型和继发性感染模型之间的小鼠阴道灌洗液和阴道组织进行了观察和比较。免疫抑制组在各时间点的菌落形成单位（CFU）平均水平均高于雌激素处理组，且峰值时间延迟。接种后第4天起，两组间差异具有统计学意义（P<0.05）。对照组与雌激素处理组之间以及对照组与免疫抑制组之间的CFU平均水平存在显著差异（P<0.05和P<0.01）。得出结论：免疫抑制小鼠的阴道黏膜对白色念珠菌更易感，原发性感染小鼠和继发性感染小鼠在易感性上未发现差异。
