乳腺干细胞和祖细胞：肿瘤前体？

Mammary stem and progenitor cells: tumour precursors?

作者信息

Paguirigan Amy, Beebe David J, Liu Bob, Alexander Caroline

机构信息

Department of Biomedical Engineering, University of Wisconsin, 1400 University Avenue, Madison 53706, USA.

出版信息

Eur J Cancer. 2006 Jun;42(9):1225-36. doi: 10.1016/j.ejca.2006.01.048. Epub 2006 May 11.

DOI:10.1016/j.ejca.2006.01.048

PMID:16697180

Abstract

Several groups have proposed that mammary epithelial cell (MEC) populations, in common with other epithelia, have stem and progenitor sub-populations that are long-lived and provide most of the growth potential during ductal (and perhaps lobuloalveolar) outgrowth. In this review, we describe what is known about normal development, particularly with respect to the growth potential and regenerative capacity of mouse MEC populations. We have developed a theoretical model in order to understand how the activity of the somatic stem/progenitor cell compartment during mammary gland development could affect the demographic of adult MEC populations. This demographic is likely to be key to understanding tumour risk, since long-lived cells provide great advantages in the process of cancer development.

摘要

有几个研究小组提出，与其他上皮组织一样，乳腺上皮细胞（MEC）群体中存在长期存活的干细胞和祖细胞亚群，它们在导管（可能还有小叶腺泡）生长过程中提供了大部分的生长潜能。在这篇综述中，我们描述了关于正常发育的已知情况，特别是小鼠MEC群体的生长潜能和再生能力。我们建立了一个理论模型，以了解乳腺发育过程中体细胞干细胞/祖细胞区室的活性如何影响成年MEC群体的统计学特征。这种统计学特征可能是理解肿瘤风险的关键，因为长寿细胞在癌症发展过程中具有很大优势。