棘阿米巴角膜炎的免疫生物学

The immunobiology of Acanthamoeba keratitis.

作者信息

Clarke Daniel W, Niederkorn Jerry Y

机构信息

Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9057, USA.

出版信息

Microbes Infect. 2006 Apr;8(5):1400-5. doi: 10.1016/j.micinf.2005.12.009. Epub 2006 Feb 9.

DOI:10.1016/j.micinf.2005.12.009

PMID:16697233

Abstract

Acanthamoeba spp. are free-living amoebae that cause Acanthamoeba keratitis, a blinding corneal infection. The innate immune apparatus is crucial for the resolution of the disease. With the exception of mucosal antibody, elements of the adaptive immune system fail to prevent infection or contribute to its resolution in experimental animals.

摘要

棘阿米巴属是自由生活的变形虫，可引起棘阿米巴角膜炎，这是一种致盲性角膜感染。固有免疫系统对于疾病的消退至关重要。除黏膜抗体外，适应性免疫系统的成分在实验动物中无法预防感染或促进其消退。