尤因肉瘤：来自罕见模型的总体见解

Ewing's sarcoma: general insights from a rare model.

作者信息

Davis Sean, Meltzer Paul S

机构信息

Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Cancer Cell. 2006 May;9(5):331-2. doi: 10.1016/j.ccr.2006.05.003.

DOI:10.1016/j.ccr.2006.05.003

PMID:16697953

Abstract

Ewing's sarcoma is characterized by the presence of fusion oncoproteins involving EWSR1 and an ETS gene, most commonly FLI1. In this issue of Cancer Cell, Smith et al. have combined RNA interference with expression profiling to study the pattern of gene expression downstream of the most common of these fusions, EWS/FLI. Using this strategy, Smith et al. have identified a homeobox gene, NKX2.2, which is both highly expressed in Ewing's sarcoma and essential for the transforming activity of EWS/FLI.

摘要

尤因肉瘤的特征是存在涉及EWSR1和一个ETS基因（最常见的是FLI1）的融合癌蛋白。在本期《癌细胞》杂志中，史密斯等人将RNA干扰与表达谱分析相结合，以研究这些最常见融合体（EWS/FLI）下游的基因表达模式。运用这一策略，史密斯等人鉴定出一个同源框基因NKX2.2，它在尤因肉瘤中高表达，并且对于EWS/FLI的转化活性至关重要。