Zorowitz Richard D, Smout Randall J, Gassaway Julie A, Horn Susan D
Physical Medicine and Rehabilitation, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Top Stroke Rehabil. 2005 Fall;12(4):37-49. doi: 10.1310/C7MF-VLR0-CKDL-3C44.
Pain remains one of the most common, yet most challenging, medical problems in health care today, and it is one of the most common complications that occurs after a stroke. Pain can affect the course of stroke rehabilitation adversely, and it occasionally may be a cause for transfer back to an acute care hospital. The Post-Stroke Rehabilitation Outcomes Project (PSROP) database was used to describe the incidence of pain by body location and trends in the use of different classifications of medications to treat pain. Of the 1,122 participants in the PSROP database, the most common locations of pain in stroke survivors were the head, leg, back, and shoulder. The most frequently prescribed classifications of pain medications were other analgesics (acetaminophen and tramadol), followed by narcotic analgesics, non-steroidal antiinflammatory drugs (NSAIDs), anticonvulsants, and tricyclic antidepressants. After acetaminophen, the most frequently prescribed medications in each classification, respectively, include hydrocodone APAP, cox-2 inhibitors, gabapentin, and amitriptyline. Other frequently prescribed pain medications included sumatriptan (migraine analgesic), cyclobenzaprine (muscle relaxant), and baclofen (antispasticity muscle relaxant). Medications should be chosen based upon the medical condition causing pain, the ability of the stroke survivor to comply with administration of the medication, and the cost of the medication. Appropriate and timely treatments of painful conditions result in maximum function and the ability to lead active lives and maintain an adequate quality of life.
疼痛仍是当今医疗保健中最常见但也最具挑战性的医学问题之一,并且是中风后最常见的并发症之一。疼痛会对中风康复进程产生不利影响,偶尔还可能成为转回急症医院的原因。中风后康复结果项目(PSROP)数据库被用于描述按身体部位划分的疼痛发生率以及使用不同分类药物治疗疼痛的趋势。在PSROP数据库的1122名参与者中,中风幸存者最常见的疼痛部位是头部、腿部、背部和肩部。最常开具的止痛药物分类是其他镇痛药(对乙酰氨基酚和曲马多),其次是麻醉性镇痛药、非甾体抗炎药(NSAIDs)、抗惊厥药和三环类抗抑郁药。在对乙酰氨基酚之后,各分类中最常开具的药物分别是氢可酮对乙酰氨基酚、环氧化酶-2抑制剂、加巴喷丁和阿米替林。其他经常开具的止痛药物包括舒马曲坦(偏头痛镇痛药)、环苯扎林(肌肉松弛剂)和巴氯芬(抗痉挛肌肉松弛剂)。应根据引起疼痛的病情、中风幸存者遵医嘱用药的能力以及药物成本来选择药物。对疼痛状况进行适当及时的治疗可实现最大功能,并使人有能力积极生活并维持足够的生活质量。