Laviolette S R, Grace A A
Department of Neuroscience, The University of Pittsburgh, Pittsburgh, 458 Crawford Hall, Pennsylvania 15260, USA.
Cell Mol Life Sci. 2006 Jul;63(14):1597-613. doi: 10.1007/s00018-006-6027-5.
Cannabinoids represent one of the most widely used hallucinogenic drugs and induce profound alterations in sensory perception and emotional processing. Similarly, the dopamine (DA) neurotransmitter system is critical for the central processing of emotion and motivation. Functional disturbances in either of these neurotransmitter systems are well-established correlates of the psychopathological symptoms and behavioral manifestations observed in addiction and schizophrenia. Increasing evidence from the anatomical, pharmacological and behavioral neuroscience fields points to complex functional interactions between these receptor systems at the anatomical, pharmacological and neural systems levels. An important question relates to whether these systems act in an orchestrated manner to produce the emotional processing and sensory perception deficits underlying addiction and schizophrenia. This review describes evidence for functional neural interactions between cannabinoid and DA receptor systems and how disturbances in this neural circuitry may underlie the aberrant emotional learning and processing observed in disorders such as addiction and schizophrenia.
大麻素是使用最为广泛的致幻药物之一，会引起感觉认知和情绪处理方面的深刻变化。同样，多巴胺（DA）神经递质系统对情绪和动机的中枢处理至关重要。这两种神经递质系统中任何一种的功能紊乱，都是成瘾和精神分裂症中观察到的精神病理症状和行为表现的既定相关因素。来自解剖学、药理学和行为神经科学领域的越来越多的证据表明，这些受体系统在解剖学、药理学和神经系统层面存在复杂的功能相互作用。一个重要的问题是，这些系统是否以协调的方式发挥作用，以产生成瘾和精神分裂症等疾病中潜在的情绪处理和感觉认知缺陷。这篇综述描述了大麻素和DA受体系统之间功能性神经相互作用的证据，以及这种神经回路的紊乱如何可能是成瘾和精神分裂症等疾病中观察到的异常情绪学习和处理的基础。
