Immunological and immunogenetic markers in sporadic Alzheimer's disease.
作者信息
Lio Domenico, Scola Letizia, Romano Giuseppina Colonna, Candore Giuseppina, Caruso Calogero
机构信息
Gruppo di studio sull'immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Italy.
出版信息
Aging Clin Exp Res. 2006 Apr;18(2):163-6. doi: 10.1007/BF03327434.
BACKGROUND
Common polymorphisms of genes controlling inflammation-modulating cytokines and acute-phase proteins which play important roles in the pathogenesis of Alzheimer's disease (AD) have been shown to be associated with AD.
AIMS
The immunological and immunogenetic markers potentially useful for the AD risk evaluation and diagnosis are briefly reviewed.
CONCLUSION
The state-of-the-art of immunological and immunogenetic markers of AD indicates that new tools and strategies are necessary to identify gene products useful as diagnostic tools.
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