“Bak（以及Bax）走向未来”——关于原发性黑色素瘤的预后？

"Bak (and Bax) to the future"--of primary melanoma prognosis?

作者信息

Leverkus Martin, Gollnick Harald

机构信息

Laboratory for Experimental Dermatology, Department of Dermatology and Venereology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.

出版信息

J Invest Dermatol. 2006 Jun;126(6):1212-4. doi: 10.1038/sj.jid.5700239.

DOI:10.1038/sj.jid.5700239

PMID:16702969

Abstract

Bcl-2 proteins either block or activate the "intrinsic" mitochondrial apoptosis pathway. Loss of expression of proapoptotic Bcl-2 proteins, namely Bax and Bak, in primary melanomas is associated with a worse long-term prognosis. Consequently, inactivation of mitochondrial signaling pathways of apoptosis may not only be a prerequisite for melanoma progression but may also hamper therapeutic efforts with chemotherapeutic drugs.

摘要

Bcl-2蛋白可阻断或激活“内源性”线粒体凋亡途径。原发性黑色素瘤中促凋亡Bcl-2蛋白（即Bax和Bak）表达缺失与较差的长期预后相关。因此，线粒体凋亡信号通路的失活不仅可能是黑色素瘤进展的前提条件，还可能阻碍化疗药物的治疗效果。