Villalobo Antonio
Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid, Spain.
FEBS J. 2006 Jun;273(11):2329-44. doi: 10.1111/j.1742-4658.2006.05250.x.
Nitric oxide (NO*) has been proposed to be a physiological modulator of cell proliferation, able to promote in most cases cell cycle arrest. In this review I explore the molecular basis of this mechanism of action. The modulatory action of NO* on the intracellular concentration of cGMP and the machinery directly involved in the control of cell cycle progression, including the expression and activity of diverse cyclins and cyclin-dependent kinases, their physiological inhibitors, and the master transcriptional regulator retinoblastoma protein, will be discussed. The role of NO* in proliferation mediated by tyrosine kinase receptors such as the epidermal growth factor receptor and downstream signalling pathways will also be considered. Finally, the involvement of NO* in proliferative processes relevant for normal development will be outlined.
一氧化氮（NO*）被认为是细胞增殖的一种生理调节因子，在大多数情况下能够促进细胞周期停滞。在这篇综述中，我将探讨这种作用机制的分子基础。将讨论NO对细胞内cGMP浓度的调节作用以及直接参与细胞周期进程控制的机制，包括各种细胞周期蛋白和细胞周期蛋白依赖性激酶的表达和活性、它们的生理抑制剂以及主要转录调节因子视网膜母细胞瘤蛋白。还将考虑NO在由酪氨酸激酶受体（如表皮生长因子受体）介导的增殖以及下游信号通路中的作用。最后，将概述NO*在与正常发育相关的增殖过程中的参与情况。
