在衰老加速小鼠中，神经分泌系统肥大。
The neurosecretory system is hypertrophied in senescence-accelerated mice.
作者信息
Crespo Damaso, Megias Manuel, Fernandez-Viadero Carlos, Alonso Laura, Verduga Rosario
机构信息
Biogerontology Unit, Department of Anatomy and Cell Biology, Faculty of Medicine, University of Cantabria, Santander, Spain.
出版信息
Rejuvenation Res. 2006 Summer;9(2):297-301. doi: 10.1089/rej.2006.9.297.
The hypothalamic supraoptic and paraventricular nuclei form the neurosecretory system and synthesize the neurohormones oxytocin and arginine-vasopressin. The senescence-accelerated mouse is a model of rapid aging that displays senile amyloidosis and memory problems. This paper presents the characterization of the neurosecretory system and describes the presence of a bilateral constant cluster of neurosecretory neurons in these mice. The stereologic analysis revealed that these groups contain 197 +/- 18 cells (87% synthesize arginine-vasopressin and 13% oxytocin). The presence of these clusters of neurosecretory neurons suggests that these mice could present greater neurohormone synthesis, increasing the deleterious effects of accelerated aging in this strain.
下丘脑视上核和室旁核构成神经分泌系统，并合成神经激素催产素和精氨酸加压素。快速老化小鼠是一种快速衰老的模型，表现出老年淀粉样变性和记忆问题。本文介绍了神经分泌系统的特征，并描述了这些小鼠中双侧恒定的神经分泌神经元簇的存在。体视学分析显示，这些组包含197±18个细胞（87%合成精氨酸加压素，13%合成催产素）。这些神经分泌神经元簇的存在表明，这些小鼠可能具有更强的神经激素合成能力，从而增加了该品系加速衰老的有害影响。
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