[芳香化酶细胞色素P450及CA125检测对子宫内膜异位症的诊断价值]
[Diagnostic value of the detection of aromatase cytochrome P450 and CA125 for endometriosis].
作者信息
Zeng Fei, Xue Min
机构信息
Department of Obstetrics and Gynecology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Dec;30(6):682-5.
OBJECTIVE
To evaluate the diagnostic value of examining endometrial biopsy specimens for aromatase cytochrome P450 and CA125 for endometriosis.
METHODS
The expression of aromatase cytochrome P450 in endometrium was detected by immunohistochemical analysis for 36 endometriosis women and 22 non-endometriosis but subfertility or pelvic pain women served as controls; the serum CA125 levels were measured by chemical radiation method.
RESULTS
By measuring serum CA125, the sensitivity of the serum CA125 assay was 44%, the specificity was 82%, the positive predictive value was 80%, and the negative predictive value was 47%; the sensitivity of aromatase cytochrome P450 in biopsy endometrium of endometriosis was 82%, the specificity was 59%, the positive predictive value was 76%, and the negative predictive value was 67%.
CONCLUSION
The combination assay of aromatase cytochrome P450 in eutopic endometrium and CA125 can be used as a diagnostic test for endometriosis, especially for the early stage of endometriosis, which is superior to the assay of CA125.
目的
评估检测子宫内膜活检标本中芳香化酶细胞色素P450和CA125对子宫内膜异位症的诊断价值。
方法
采用免疫组织化学分析法检测36例子宫内膜异位症患者子宫内膜中芳香化酶细胞色素P450的表达，以22例非子宫内膜异位症但存在不孕或盆腔疼痛的患者作为对照；采用化学发光法测定血清CA125水平。
结果
检测血清CA125时，血清CA125检测的敏感性为44%，特异性为82%，阳性预测值为80%，阴性预测值为47%；子宫内膜异位症患者活检子宫内膜中芳香化酶细胞色素P450的敏感性为82%，特异性为59%，阳性预测值为76%，阴性预测值为67%。
结论
在位子宫内膜中芳香化酶细胞色素P450与CA125联合检测可作为子宫内膜异位症的诊断方法，尤其对于子宫内膜异位症早期，其优于CA125检测。
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