Ramadan Hassan H
Department of Otolaryngology - Head and Neck Surgery, West Virginia University, Morgantown, West Virginia 26506-9200, USA.
Curr Opin Otolaryngol Head Neck Surg. 2006 Jun;14(3):183-6. doi: 10.1097/01.moo.0000193177.62074.fd.
Recently, there has been increased interest in bacterial biofilms as a major factor in chronic infections. Chronic rhinosinusitis is one of the most common chronic infections seen by physicians. The purpose of this review is to summarize the literature available on chronic rhinosinusitis and biofilms.
Only very few articles are available about the relationship between biofilms and chronic rhinosinusitis. Three separate authors reported on finding biofilms in samples obtained from patients with chronic rhinosinusitis. One article demonstrated biofilms on samples obtained from animals that were inoculated with bacteria. The major breakthrough was noted when the majority of samples from patients with chronic rhinosinusitis had biofilms in them but none were found on similar samples obtained on controls.
Even though only a few reports are available about the role of biofilms and chronic rhinosinusitis, the evidence seems to be convincing that such a role exists. We still have a long way to go, however, before we know the exact relationship of biofilms and chronic rhinosinusitis. Why do some patients form biofilms, what triggers biofilm formation and how can we prevent them from forming are questions that need to be answered.
近来，细菌生物膜作为慢性感染的一个主要因素受到越来越多的关注。慢性鼻窦炎是医生所见最常见的慢性感染之一。本综述的目的是总结有关慢性鼻窦炎和生物膜的现有文献。
关于生物膜与慢性鼻窦炎之间关系的文章非常少。三位不同的作者报告了在慢性鼻窦炎患者样本中发现生物膜的情况。一篇文章展示了在接种细菌的动物样本中存在生物膜。当慢性鼻窦炎患者的大多数样本中都有生物膜，而在对照组的类似样本中未发现生物膜时，取得了重大突破。
尽管关于生物膜在慢性鼻窦炎中的作用仅有少数报道，但证据似乎令人信服地表明这种作用是存在的。然而，在我们了解生物膜与慢性鼻窦炎的确切关系之前，我们还有很长的路要走。为什么有些患者会形成生物膜、什么触发了生物膜的形成以及我们如何预防它们的形成，这些问题都需要得到解答。
