Suppr超能文献

苦味受体与人类苦味感知

Bitter taste receptors and human bitter taste perception.

作者信息

Behrens M, Meyerhof W

机构信息

Dept. Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.

出版信息

Cell Mol Life Sci. 2006 Jul;63(13):1501-9. doi: 10.1007/s00018-006-6113-8.

Abstract

A vast number of structurally diverse bitter compounds need to be detected by a subfamily of only approximately 25 human bitter receptors. Failure in detecting them might be lethal, since some naturally occurring bitter compounds, such as strychnine, are very toxic. This review presents an overview about the enormous progress in the field of mammalian bitter taste research with special emphasis on humans, if data were available. It summarizes the current knowledge about the anatomical basis for bitter taste perception, intracellular signal transduction, evolution, expression and polymorphisms of hTAS2R genes, and the molecular basis for the recognition of bitter compounds.

摘要

大量结构各异的苦味化合物需要由仅约25种人类苦味受体组成的一个亚家族来检测。无法检测到它们可能是致命的,因为一些天然存在的苦味化合物,如马钱子碱,具有很强的毒性。如果有数据的话,本综述将概述哺乳动物苦味研究领域的巨大进展,特别着重于人类。它总结了目前关于苦味感知的解剖学基础、细胞内信号转导、进化、hTAS2R基因的表达和多态性以及苦味化合物识别的分子基础的知识。

相似文献

1
Bitter taste receptors and human bitter taste perception.
Cell Mol Life Sci. 2006 Jul;63(13):1501-9. doi: 10.1007/s00018-006-6113-8.
3
Mammalian bitter taste perception.
Results Probl Cell Differ. 2009;47:203-20. doi: 10.1007/400_2008_5.
4
The sweet and the bitter of mammalian taste.
Curr Opin Neurobiol. 2004 Aug;14(4):423-7. doi: 10.1016/j.conb.2004.06.003.
5
The bad taste of medicines: overview of basic research on bitter taste.
Clin Ther. 2013 Aug;35(8):1225-46. doi: 10.1016/j.clinthera.2013.06.007. Epub 2013 Jul 22.
6
The Growing Complexity of Human Bitter Taste Perception.
J Agric Food Chem. 2024 Jul 3;72(26):14530-14534. doi: 10.1021/acs.jafc.4c02465. Epub 2024 Jun 24.
7
Taste perception: from the tongue to the testis.
Mol Hum Reprod. 2013 Jun;19(6):349-60. doi: 10.1093/molehr/gat009. Epub 2013 Feb 18.
8
Evolution: a study in bad taste?
Curr Biol. 2005 Oct 11;15(19):R805-7. doi: 10.1016/j.cub.2005.09.021.
9
Clinical Role of Extraoral Bitter Taste Receptors.
Int J Mol Sci. 2020 Jul 21;21(14):5156. doi: 10.3390/ijms21145156.
10
Bitter taste receptors and their cells.
Ann N Y Acad Sci. 2009 Jul;1170:111-5. doi: 10.1111/j.1749-6632.2009.03897.x.

引用本文的文献

1
Generation and functional characterization of tuft cells in non-human primate pancreatic ducts through organoid culture systems.
Front Cell Dev Biol. 2025 May 6;13:1593226. doi: 10.3389/fcell.2025.1593226. eCollection 2025.
2
Predicting multiple taste sensations with a multiobjective machine learning method.
NPJ Sci Food. 2024 Jul 25;8(1):47. doi: 10.1038/s41538-024-00287-6.
4
Can humans smell tastants?
Chem Senses. 2024 Jan 1;49. doi: 10.1093/chemse/bjad054.
5
Investigating the Link between Eating Attitudes, Taste and Odour Preferences and the Chemical Senses.
Biology (Basel). 2023 Nov 10;12(11):1415. doi: 10.3390/biology12111415.
6
Bitter taste sensitivity in domestic dogs (Canis familiaris) and its relevance to bitter deterrents of ingestion.
PLoS One. 2022 Nov 30;17(11):e0277607. doi: 10.1371/journal.pone.0277607. eCollection 2022.
8
Field-Effect Sensors Using Biomaterials for Chemical Sensing.
Sensors (Basel). 2021 Nov 26;21(23):7874. doi: 10.3390/s21237874.
9
Bitter Taste Receptors in the Airway Cells Functions.
Handb Exp Pharmacol. 2022;275:203-227. doi: 10.1007/164_2021_436.
10
Structure-Function Analyses of Human Bitter Taste Receptors-Where Do We Stand?
Molecules. 2020 Sep 26;25(19):4423. doi: 10.3390/molecules25194423.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验