Doros Leslie, Kaste Sue C, Rodriguez-Galindo Carlos
Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Pediatr Blood Cancer. 2008 Feb;50(2):388-90. doi: 10.1002/pbc.20915.
Umbilical metastases, also named Sister Mary Joseph's nodules, are well documented in the adult population and most often represent an underlying intra-abdominal malignancy, usually a carcinoma of gastrointestinal or gynecologic origin. They are indicative of widespread abdominal disease and are associated with a poor prognosis. An extensive review of the literature reveals only two such presentations in the pediatric population. A 14-year-old male presented with an umbilical mass, which was found to be a metastatic lesion of a desmoplastic small round cell tumor (DSRCT) of the abdomen. The diagnosis of an intra-abdominal malignancy, most commonly a DSRCT, should be considered in the presence of an umbilical mass in a child.
脐部转移瘤，也称为玛丽·约瑟夫修女结节，在成人中已有充分记载，最常见的是代表潜在的腹内恶性肿瘤，通常是胃肠道或妇科来源的癌。它们提示广泛的腹部疾病，且预后不良。对文献的广泛回顾显示，儿科患者中仅有两例此类病例报告。一名14岁男性患者出现脐部肿块，经检查发现是腹部促结缔组织增生性小圆细胞肿瘤（DSRCT）的转移灶。儿童出现脐部肿块时，应考虑腹内恶性肿瘤的诊断，最常见的是DSRCT。
