无水酒精辅助治疗长骨骨巨细胞瘤的外科手术
Surgical treatment of giant cell tumour of long bone with anhydrous alcohol adjuvant.
作者信息
Oh Joo Han, Yoon Pil Whan, Lee Sang Hoon, Cho Hwan Seong, Kim Woo Sung, Kim Han-Soo
机构信息
Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seoul, South Korea.
出版信息
Int Orthop. 2006 Dec;30(6):490-4. doi: 10.1007/s00264-006-0154-3. Epub 2006 May 31.
This study was designed to evaluate the feasibility and effectiveness of the use of anhydrous alcohol as an adjuvant treatment for giant cell tumours (GCTs) of long bone. Between October 1989 and January 2004, 42 GCT patients were treated and followed up for an average of 4.1 years (range 1-13 years). Mean patient age was 34 years (range 17-67 years). After curettage and additional burring, anhydrous alcohol was used as an adjuvant therapy in all patients before the bone defect was filled with bone graft or cement. Four patients (9.5%) experienced local recurrence. There were no alcohol-related complications. Recurrence-free probability was 87.6% at final follow-up (13 years) after index surgery by Kaplan-Meyer analysis. Our data suggest that anhydrous alcohol can be used as an effective safe adjuvant for the treatment of GCT of long bone.
本研究旨在评估使用无水酒精作为长骨巨细胞瘤（GCT）辅助治疗的可行性和有效性。1989年10月至2004年1月期间，对42例GCT患者进行了治疗并随访，平均随访4.1年（范围1 - 13年）。患者平均年龄为34岁（范围17 - 67岁）。在刮除和额外打磨后，所有患者在骨缺损用骨移植或骨水泥填充之前，均使用无水酒精作为辅助治疗。4例患者（9.5%）出现局部复发。未发生与酒精相关的并发症。通过Kaplan - Meyer分析，在首次手术后的最终随访（13年）时，无复发生存概率为87.6%。我们的数据表明，无水酒精可作为治疗长骨GCT的一种有效且安全的辅助剂。
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