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[碘缺乏大鼠后代背侧海马和小脑皮质的局部血流]

[Local blood flow in the dorsal hippocampus and cerebellar cortex in progeny of iodine-deficient rats].

作者信息

Gabrichidze G O, Lazrishvili N I, Metreveli D S, Bekaia G L, Mitagvariia N P

出版信息

Ross Fiziol Zh Im I M Sechenova. 2006 Mar;92(3):292-8.

Abstract

Experimental studies show depressive behavior in rats caused by hypothyroidism and antidepressant effect of thyroid hormones. The present study analyses changes in the hippocampal and cerebellar cortex local blood flow in the progeny of rats suffering from iodine deficiency before mating and during the whole period of gestation. The diet with very low iodine content results in a decrease of local blood flow in both brain structures, but the greatest changes were observed in hippocampus. Addition of the iodine to the diet eliminates the above blood flow changes.

摘要

实验研究表明,甲状腺功能减退会导致大鼠出现抑郁行为,而甲状腺激素具有抗抑郁作用。本研究分析了在交配前和整个妊娠期患有碘缺乏症的大鼠后代海马体和小脑皮质局部血流的变化。碘含量极低的饮食会导致这两个脑区结构的局部血流减少,但海马体中的变化最为显著。在饮食中添加碘可消除上述血流变化。

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