ω-3脂肪酸治疗儿童抑郁症：一项对照双盲试验研究
Omega-3 treatment of childhood depression: a controlled, double-blind pilot study.
作者信息
Nemets Hanah, Nemets Boris, Apter Alan, Bracha Ziva, Belmaker R H
机构信息
Faculty of Health Sciences, Ben Gurion University of the Negev, Israel.
出版信息
Am J Psychiatry. 2006 Jun;163(6):1098-100. doi: 10.1176/ajp.2006.163.6.1098.
OBJECTIVE
Major depressive disorder in children may be more common than previously thought, and its therapeutics are unclear. Because of success in a previous study on omega-3 fatty acids in adult major depressive disorder, the authors planned a pilot study of omega-3 fatty acids in childhood major depression.
METHOD
Children who entered the study were between the ages of 6 and 12. Ratings were performed at baseline and at 2, 4, 8, 12, and 16 weeks using Children's Depression Rating Scale (CDRS), Children's Depression Inventory (CDI), and Clinical Global Impression (CGI). Children were randomized to omega-3 fatty acids or placebo as pharmacologic monotherapy. Twenty-eight patients were randomized, and 20 completed at least 1 month's ratings.
RESULTS
Analysis of variance showed highly significant effects of omega-3 on symptoms using the CDRS, CDI, and CGI.
CONCLUSIONS
Omega-3 fatty acids may have therapeutic benefits in childhood depression.
目的
儿童重度抑郁症可能比之前认为的更为常见，其治疗方法尚不清楚。鉴于之前一项关于ω-3脂肪酸治疗成人重度抑郁症的研究取得成功，作者计划开展一项关于ω-3脂肪酸治疗儿童重度抑郁症的试点研究。
方法
进入该研究的儿童年龄在6至12岁之间。在基线以及第2、4、8、12和16周时，使用儿童抑郁评定量表（CDRS）、儿童抑郁量表（CDI）和临床总体印象量表（CGI）进行评分。儿童被随机分为接受ω-3脂肪酸或安慰剂作为药物单一疗法。28名患者被随机分组，20名完成了至少1个月的评分。
结果
方差分析显示，使用CDRS、CDI和CGI时，ω-3对症状有高度显著的影响。
结论
ω-3脂肪酸可能对儿童抑郁症有治疗益处。
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