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前庭神经鞘瘤伽玛刀治疗后的功能转归

Functional outcome after gamma knife treatment in vestibular schwannoma.

作者信息

Hempel J M, Hempel E, Wowra B, Schichor Ch, Muacevic A, Riederer A

机构信息

Department of ENT, Head and Neck Surgery, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany.

出版信息

Eur Arch Otorhinolaryngol. 2006 Aug;263(8):714-8. doi: 10.1007/s00405-006-0054-6. Epub 2006 Jun 2.

Abstract

Radiosurgery (RS) is a noninvasive, ambulatory special neurosurgical procedure for the treatment of vestibular schwannoma (VS). We treated 123 patients with unilateral schwannomas between 1994 and 2000 at the gamma knife (GK) center in Munich using a primary stereotactic procedure. These patients were followed up until June 2004 in respect to audiological, neurological, neurootological and radiological features before and after radiosurgical intervention. The actual tumor control rate of 8.2 years (mean) after GK surgery for all patients and a single treatment was calculated to be 96.7%. The impairment of hearing was on average 18% after GK, ranking from 0% gain of hearing loss up to 90%. Facial nerve function, graded according to the House-Brackmann scale, deteriorated in none of the patients; 5.8% reported a trigeminal neuralgia. Tinnitus developed in 4.1% of the patients after RS; 13.3% had vertigo for the first time after the treatment, age apparently being a predisposing factor. Radiosurgical treatment for VS is an alternative to microsurgery (MS). It is associated with a lower rate of facial and trigeminal neuropathy, postoperative complications and hospital stay. The hearing preservation rate is equivalent to MS.

摘要

放射外科(RS)是一种用于治疗前庭神经鞘瘤(VS)的非侵入性、可门诊进行的特殊神经外科手术。1994年至2000年期间,我们在慕尼黑的伽玛刀(GK)中心采用原发性立体定向手术治疗了123例单侧神经鞘瘤患者。对这些患者在放射外科干预前后的听力学、神经学、神经耳科学和放射学特征进行随访,直至2004年6月。所有患者单次GK手术后平均8.2年的实际肿瘤控制率计算为96.7%。GK术后听力损害平均为18%,听力损失改善率从0%到90%不等。根据House-Brackmann量表分级,无一例患者面神经功能恶化;5.8%的患者报告有三叉神经痛。RS术后4.1%的患者出现耳鸣;13.3%的患者在治疗后首次出现眩晕,年龄显然是一个诱发因素。VS的放射外科治疗是显微手术(MS)的一种替代方法。它与较低的面神经和三叉神经病变率、术后并发症及住院时间相关。听力保留率与MS相当。

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