细胞和血小板对星形八臂聚（乙二醇）-聚（L-丙交酯）嵌段共聚物薄膜粘附的抑制作用

Suppression of cell and platelet adhesion to star-shaped 8-armed poly(ethylene glycol)-poly(L-lactide) block copolymer films.

作者信息

Nagahama Koji, Ohya Yuichi, Ouchi Tatsuro

机构信息

Department of Applied Chemistry, Faculty of Engineering and High Technology Research Center, Kansai University, Suita, Osaka 564-8680, Japan.

出版信息

Macromol Biosci. 2006 Jun 16;6(6):412-9. doi: 10.1002/mabi.200500249.

DOI:10.1002/mabi.200500249

PMID:16741900

Abstract

To explore the potential of a star-shaped 8-armed poly(ethylene glycol)35K-block-poly(L-lactide)37K (8-armed PEG35K-b-PLLA37K: M(n) of PEG = 35 000, M(n) of PLLA = 37 000) film as a novel bioabsorbable adhesion-prevention membrane, the water structure, surface contact angle, protein adsorption, and cell and platelet anti-adhesion properties of such a hydrated film are investigated. Based on the results, it is found that the 8-armed PEG35K-b-PLLA37K film exhibits a biologically inert surface, which is the result of a large number of PEG chains and a free water layer on the film surface. This leads to a reduction in protein absorption and cell and platelet adhesion onto the film surface. This implies that the star-shaped 8-armed PEG35K-b-PLLA37K film can be utilized as a novel bioabsorbable adhesion-prevention membrane.

摘要

为了探索一种星形八臂聚乙二醇35K-嵌段-聚L-丙交酯37K（八臂PEG35K-b-PLLA37K：PEG的数均分子量 = 35000，PLLA的数均分子量 = 37000）薄膜作为新型可生物吸收防粘连膜的潜力，对这种水合薄膜的水结构、表面接触角、蛋白质吸附以及细胞和血小板抗粘连特性进行了研究。基于这些结果，发现八臂PEG35K-b-PLLA37K薄膜呈现出生物惰性表面，这是薄膜表面大量PEG链和自由水层的结果。这导致蛋白质吸收以及细胞和血小板在薄膜表面的黏附减少。这意味着星形八臂PEG35K-b-PLLA37K薄膜可被用作新型可生物吸收防粘连膜。