Reaction of dipeptidylpeptidase IV with substrate-analogous azapeptides.
作者信息
Neumann U, Steinmetzer T, Barth A, Demuth H U
机构信息
Institute of Pharmacology and Toxicology, Medical Academy Erfurt, GDR.
出版信息
J Enzyme Inhib. 1991;4(3):213-26. doi: 10.3109/14756369109035845.
PMID:1674753
Abstract
The reaction of dipeptidyl peptidase IV (EC 3.4.14.5.) with azapeptide substrates containing azaalanine or azaproline in the P1-position was investigated. Accumulation of a fairly stable acyl-enzyme could be shown for ester substrates. Ala-AzaPro-pNA is a very poor substrate of DP IV and does not accumulate an acyl-enzyme. DP IV does not react with active-site titrants for trypsin-like serine proteases.
摘要
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