[外胚层发育不良蛋白基因信号传导与汗腺发育及再生的关系]
[Relationship of ectodysplasin gene signaling with development and regeneration of sweat glands].
作者信息
Zhou Gang, Li Haihong, Fu Xiaobing
机构信息
Key Research Laboratory of the Wound Repair, the 304th Clinical Department, General Hospital of PLA, Beijing, 100037, P.R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2006 May;20(5):578-81.
OBJECTIVE
To investigate the expression of ectodysplasin (EDA) gene signaling and its relationship with the development and regeneration of sweat glands.
METHODS
The articles concerned in the latest years were extensively reviewed.
RESULTS
EDA gene is an important signaling pathway associated with the developmental procedure of sweat glands in early fetal stage. Abnormality or depletion of function in sweat glands partially owed to the defect of EDA gene.
CONCLUSION
EDA signaling has its biological significance in inducing development and morphogenesis of sweat glands and in maintaining physiological function of skin. It could be a new approach to repair or regenerate the sweat glands for clinical therapy by regulating the expression of EDA gene.
目的
探讨外胚层发育不良蛋白（EDA）基因信号通路的表达及其与汗腺发育和再生的关系。
方法
广泛查阅近年相关文献。
结果
EDA基因是与胎儿早期汗腺发育过程相关的重要信号通路。汗腺的异常或功能缺失部分归因于EDA基因缺陷。
结论
EDA信号通路在诱导汗腺发育和形态发生以及维持皮肤生理功能方面具有生物学意义。通过调节EDA基因表达来修复或再生汗腺可能为临床治疗提供新途径。
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