患原发性侧索硬化症的单卵双胞胎。

Monozygotic twins discordant for primary lateral sclerosis.

作者信息

Sorenson Eric J

机构信息

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

出版信息

Amyotroph Lateral Scler. 2006 Jun;7(2):123-5. doi: 10.1080/14660820600601135.

DOI:10.1080/14660820600601135

PMID:16753978

Abstract

The genetics of the motor neuron diseases are becoming increasingly important. The relationship of primary lateral sclerosis and amyotrophic lateral sclerosis remains debated. Here a pair of monozygotic twins discordant for primary lateral sclerosis is presented. This monozygotic twin pair suggests that environmental factors were most relevant to this subject's development of primary lateral sclerosis. Their life history suggests very similar social and professional exposures without any apparent distinctions.

摘要

运动神经元疾病的遗传学正变得越来越重要。原发性侧索硬化症与肌萎缩侧索硬化症之间的关系仍存在争议。本文介绍了一对患原发性侧索硬化症的同卵双胞胎。这对同卵双胞胎表明环境因素与该患者原发性侧索硬化症的发病最为相关。他们的生活史显示出非常相似的社会和职业接触情况，没有任何明显差异。