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针对重度残疾慢性疼痛患者的情境认知行为疗法:有效性及具有临床意义的改变

Contextual cognitive-behavioral therapy for severely disabled chronic pain sufferers: effectiveness and clinically significant change.

作者信息

McCracken Lance M, MacKichan Fiona, Eccleston Christopher

机构信息

Pain Management Unit, Royal National Hospital for Rheumatic Diseases, University of Bath, Upper Borough Walls, Bath BA1 1RL, UK.

出版信息

Eur J Pain. 2007 Apr;11(3):314-22. doi: 10.1016/j.ejpain.2006.05.004. Epub 2006 Jun 9.

Abstract

Interdisciplinary pain management programs have an established record of significantly improving the functioning of persons disabled with chronic pain. There is a group of pain sufferers, however, who have difficulty accessing these programs and for whom the effectiveness of these treatments in unknown, these are patients whose mobility and self-care deficits leave them unable to meet the practical demands of many treatment environments. The purpose of this study was to examine the results of a treatment program designed to meet the needs of these highly disabled individuals (n=53) in comparison to results obtained from a standard less-disabled group attending treatment at the same facility (n=234). Results from the highly disabled patients showed statistically significant change after treatment in eight of nine outcome variables, including improvements in pain-related distress, disability, depression, pain-related anxiety, daytime rest, and performance during an activity tolerance test. Effect size calculations showed a number of large treatment effects, for psychosocial disability, depression, and acceptance of pain. Analysis of reliable change and clinical significance demonstrated that results were not merely statistically significant but clinically meaningful. Results appeared stable at three months following treatment. This research plays an important part in establishing an evidence base to inform service development, ensuring that chronic pain services do not exclude people on the basis of the severity of their disability.

摘要

跨学科疼痛管理项目在显著改善慢性疼痛致残者的功能方面有着既定的记录。然而,有一群疼痛患者难以获得这些项目,而且这些治疗对他们的有效性尚不清楚,这些患者的行动能力和自我护理缺陷使他们无法满足许多治疗环境的实际要求。本研究的目的是,与在同一机构接受治疗的残疾程度较低的标准组(n = 234)所获得的结果相比,检验一个旨在满足这些高度残疾个体(n = 53)需求的治疗项目的结果。高度残疾患者的结果显示,在九个结果变量中的八个变量上,治疗后有统计学上的显著变化,包括疼痛相关困扰、残疾、抑郁、疼痛相关焦虑、白天休息以及活动耐力测试期间的表现有所改善。效应量计算显示,在心理社会残疾、抑郁和对疼痛的接受度方面有一些较大的治疗效果。可靠变化分析和临床意义分析表明,结果不仅在统计学上显著,而且在临床上有意义。治疗后三个月结果似乎稳定。这项研究在建立一个为服务发展提供信息的证据基础方面发挥着重要作用,确保慢性疼痛服务不会因残疾严重程度而将人们排除在外。

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