Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1alpha,25-dihydroxyvitamin D3.
作者信息
Sinishtaj Sandra, Jeon Heung Bae, Dolan Patrick, Kensler Thomas W, Posner Gary H
机构信息
Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA.
出版信息
Bioorg Med Chem. 2006 Sep 15;14(18):6341-8. doi: 10.1016/j.bmc.2006.05.050. Epub 2006 Jun 12.
PMID:16765598
Abstract
Four new side-chain amide (2 and 3) and hydroxamate (4 and 5) analogs of the hormone calcitriol (1) have been prepared. Even though lacking the 25-OH group characteristic of natural calcitriol (1), analogs 2-4 are as antiproliferative in vitro as calcitriol (1) but are 20-40 times less calciuric in vivo than calcitriol (1).
摘要
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