Holekamp Nancy M, Shui Ying-Bo, Beebe David
Barnes Retina Institute, St Louis, Missouri, USA.
Am J Ophthalmol. 2006 Jun;141(6):1027-32. doi: 10.1016/j.ajo.2006.01.016.
To report intraocular oxygen tension in eyes of diabetic and nondiabetic patients.
A prospective, interventional consecutive case series.
Oxygen was measured with an optical oxygen sensor in patients who were undergoing vitrectomy. Before turning on the infusion fluid, intraocular oxygen tension was measured in two locations: adjacent to the lens and in the mid vitreous cavity.
Fifty eyes from 50 patients were included in the study. Twenty-one eyes were from diabetic patients and 29 eyes were from nondiabetic patients. The mean oxygen tension adjacent to the lens was significantly lower in diabetic than in nondiabetic patients (8.4 +/- 0.7 mm Hg vs 10.7 +/- 0.8 mm Hg; P < .05). Similarly, the mean oxygen tension in the center of the vitreous cavity was lower in diabetic than in nondiabetic patients (5.7 +/- 0.7 mm Hg vs 8.5 +/- 0.6 mm Hg; P < .001). In subgroup analyses, previous panretinal photocoagulation or cataract surgery did not affect oxygen levels significantly in the vitreous of diabetic or nondiabetic patients.
Eyes from diabetic patients have significantly lower intraocular oxygen tension than in eyes from nondiabetic patients. Because oxidative damage to the lens nucleus and increased intraocular oxygen tension have been associated with nuclear sclerotic cataract, these findings may help explain recent reports of an apparent protective effect of diabetes mellitus against nuclear sclerotic cataract.
报告糖尿病患者和非糖尿病患者眼内的氧张力。
一项前瞻性、干预性连续病例系列研究。
在接受玻璃体切除术的患者中，使用光学氧传感器测量氧含量。在开启灌注液之前，于两个部位测量眼内氧张力：晶状体旁和玻璃体腔中部。
本研究纳入了50例患者的50只眼。其中21只眼来自糖尿病患者，29只眼来自非糖尿病患者。糖尿病患者晶状体旁的平均氧张力显著低于非糖尿病患者（8.4±0.7 mmHg对10.7±0.8 mmHg；P<0.05）。同样，糖尿病患者玻璃体腔中央的平均氧张力低于非糖尿病患者（5.7±0.7 mmHg对8.5±0.6 mmHg；P<0.001）。在亚组分析中，既往全视网膜光凝或白内障手术对糖尿病或非糖尿病患者玻璃体中的氧水平无显著影响。
糖尿病患者眼内的氧张力显著低于非糖尿病患者。由于晶状体核的氧化损伤与眼内氧张力升高均与核性硬化性白内障有关，这些发现可能有助于解释近期有关糖尿病对核性硬化性白内障具有明显保护作用的报道。
