Mishra Asht M, Reddy Sangala J, Husain Mazhar, Behari Sanjay, Husain Nuzhat, Prasad Kashi N, Kumar Sunil, Gupta Rakesh K
Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
J Magn Reson Imaging. 2006 Jul;24(1):52-6. doi: 10.1002/jmri.20621.
To compare the signal intensity on the fluid attenuated inversion recovery (FLAIR) sequence and magnetization transfer ratios (MTRs) for the differentiation of abscesses from non-abscess cystic brain lesions, and to correlate these MR parameters with the viscosity, viable cell density and total protein concentration of the cystic fluid.
Signal intensity on FLAIR and MTRs from the cystic cavity of lesions were calculated from 33 patients (brain abscess (N = 12) and non-abscess (N = 21)). The fluid from the lesion was aspirated at the time of surgery, and the viscosity, viable cell density, and total protein concentration were measured.
Signal intensity on FLAIR correlated significantly with the total protein concentration in abscess (r = 0.60, P < 0.05) and non-abscess lesions (r = 0.41, P < 0.05). However, there was no significant difference (P > 0.05) in the FLAIR signal intensity of the abscess (318.8 +/- 75) and non-abscess group (258 +/- 47). The MTR of the brain abscesses (13 +/- 0.95) was significantly higher (P < 0.05) than that of the non-abscess group (3.5 +/- 0.3). A significant correlation was observed between MTR and viscosity (r = 0.75, P < 0.05), total protein concentration (r = 0.60, P < 0.05), and cell density (r = 0.70, P < 0.05) in brain abscess, and viscosity (r = 0.81, P < 0.05) and total protein concentration (r = 0.41, P < 0.05) in non-abscess lesions.
It is possible to differentiate brain abscesses from non-abscess cystic lesions using MT imaging. The MTR correlates significantly with the viscosity, viable cell density, and total protein concentration in brain abscess, and with viscosity and total protein concentration in non-abscess lesions. FLAIR signal intensity correlates significantly only with the total protein concentration in abscess and non-abscess lesions.
比较液体衰减反转恢复（FLAIR）序列上的信号强度和磁化传递率（MTR），以鉴别脑脓肿与非脓肿性囊性脑病变，并将这些磁共振参数与囊液的粘度、活细胞密度和总蛋白浓度进行关联。
计算33例患者（脑脓肿12例，非脓肿21例）病变囊腔内FLAIR序列上的信号强度和MTR。手术时抽取病变液体，测量其粘度、活细胞密度和总蛋白浓度。
FLAIR序列上的信号强度与脓肿（r = 0.60，P < 0.05）和非脓肿性病变（r = 0.41，P < 0.05）中的总蛋白浓度显著相关。然而，脓肿组（318.8±75）和非脓肿组（258±47）的FLAIR信号强度无显著差异（P > 0.05）。脑脓肿的MTR（13±0.95）显著高于非脓肿组（3.5±0.3）（P < 0.05）。在脑脓肿中，MTR与粘度（r = 0.75，P < 0.05）、总蛋白浓度（r = 0.60，P < 0.05）和细胞密度（r = 0.70，P < 0.05）显著相关；在非脓肿性病变中，MTR与粘度（r = 0.81，P < 0.05）和总蛋白浓度（r = 0.41，P < 0.05）显著相关。
利用磁化传递成像能够鉴别脑脓肿与非脓肿性囊性病变。脑脓肿中的MTR与粘度、活细胞密度和总蛋白浓度显著相关，在非脓肿性病变中与粘度和总蛋白浓度显著相关。FLAIR信号强度仅与脓肿和非脓肿性病变中的总蛋白浓度显著相关。
