Chan Tak Mao
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong.
Ethn Dis. 2006 Spring;16(2 Suppl 2):S2-66-9.
Systemic lupus erythematosus is more prevalent among Asians, African Americans, and Hispanics than in Caucasians. Progress in its management over the past few decades has resulted in improved patient survival, although a considerable proportion of patients are still afflicted with long-term illnesses such as chronic renal failure secondary to lupus nephritis.
This is a review of the factors that affect the survival of patients with systemic lupus erythematosus, including discussion of the measures that can further improve the clinical outcomes and prevent long-term complications. Recent advances in the treatment of severe lupus nephritis are emphasized, especially with regard to the minimization of treatment-related adverse events.
While the prognosis of patients with severe lupus manifestations continues to improve, prevention of relapse remains a clinical challenge. Concomitant attention to health economics and sociopolitical issues is required to ensure that all patients can benefit from scientific progress in the understanding and treatment of severe lupus erythematosus.
系统性红斑狼疮在亚洲人、非裔美国人和西班牙裔中比在白种人中更为普遍。在过去几十年里，其治疗取得了进展，患者生存率有所提高，尽管仍有相当一部分患者患有诸如狼疮性肾炎继发的慢性肾衰竭等长期疾病。
本文综述了影响系统性红斑狼疮患者生存的因素，包括对可进一步改善临床结局和预防长期并发症的措施的讨论。重点强调了重症狼疮性肾炎治疗的最新进展，特别是在尽量减少治疗相关不良事件方面。
虽然重症狼疮表现患者的预后持续改善，但预防复发仍是一项临床挑战。需要同时关注卫生经济学和社会政治问题，以确保所有患者都能从重症系统性红斑狼疮的认识和治疗方面的科学进展中受益。
