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[结直肠癌:风险适应性筛查及医生在该癌症预防中的作用]

[Colorectal cancer: a risk-adapted screening and the role of the physician in the prevention of this cancer].

作者信息

Chappuis P O, Hutter P

机构信息

Service d'oncologie, Service de génétique médicale, HUG, 1211 Genève 14.

出版信息

Rev Med Suisse. 2006 May 17;2(66):1314, 1316, 1318-23.

Abstract

The benefit of colorectal cancer screening in the average-risk population, as well as in the presence of high risk genetic predispositions, has been validated by a significant reduction of the mortality associated with the disease. Several screening options are recognized and compliance with these measures remains a public health problem. The physician plays a key role in the promotion of the colorectal cancer screening. Collecting a precise family history is crucial for the identification of individuals at high risk. Validated clinical criteria are helpful for the identification of individuals with a genetic predisposition to colorectal cancer. Molecular screening for the main colorectal cancer predisposing genes should now be integrated in the clinical management of these patients and their families.

摘要

在一般风险人群以及存在高风险遗传易感性的人群中,结直肠癌筛查的益处已通过与该疾病相关的死亡率显著降低得到验证。有几种筛查方法已得到认可,但对这些措施的依从性仍然是一个公共卫生问题。医生在促进结直肠癌筛查方面起着关键作用。收集准确的家族病史对于识别高危个体至关重要。经过验证的临床标准有助于识别有结直肠癌遗传易感性的个体。现在应将主要结直肠癌易感基因的分子筛查纳入这些患者及其家族的临床管理中。

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