Mamuya Simon H D, Bråtveit Magne, Mwaiselage Julius, Moen Bente E
Centre for International Health, University of Bergen, Norway.
Ann Occup Hyg. 2006 Oct;50(7):737-45. doi: 10.1093/annhyg/mel031. Epub 2006 Jun 15.
This study aims at estimating variability in exposure to respirable dust and assessing whether the a priori grouping by job team is appropriate for an exposure-response study on respiratory effects among workers in a manually operated coal mine in Tanzania. Furthermore, estimated exposure levels were used to calculate cumulative exposure. Full-shift personal respirable dust samples (n = 204) were collected from 141 randomly chosen workers at underground and surface work sites. The geometric mean exposure for respirable dust varied from 0.07 mg m(-3) for office workers to 1.96 mg m(-3) for the development team. The analogous range of respirable quartz exposure was 0.006-0.073 mg m(-3). Variance components were estimated using random effect models. For most job teams the within-worker variance component was considerably higher than the between-worker variance component. For respirable dust the estimated attenuation of the linear exposure-response relationship was low (5.9%) when grouping by job team. Grouping by job team was considered appropriate for studying the association between current dust exposure and respiratory effects. Based on the estimated worker-specific mean exposure in the job teams, the arithmetic mean cumulative exposure for the 299 workers who participated in the epidemiological part of the study was 38.1 mg* yr m(-3) for respirable dust and 2.0 mg* yr m(-3) for quartz.
本研究旨在估算可吸入粉尘暴露的变异性,并评估按作业班组进行的先验分组是否适用于坦桑尼亚一家手工煤矿工人呼吸效应的暴露-反应研究。此外,利用估算的暴露水平计算累积暴露量。从地下和地面工作场所随机选取的141名工人中采集了全时段个人可吸入粉尘样本(n = 204)。可吸入粉尘的几何平均暴露量从办公室工作人员的0.07 mg/m³到开拓班组的1.96 mg/m³不等。可吸入石英的相应范围为0.006 - 0.073 mg/m³。使用随机效应模型估算方差分量。对于大多数作业班组,工人内部方差分量远高于工人之间的方差分量。对于可吸入粉尘,按作业班组分组时,线性暴露-反应关系的估计衰减较低(5.9%)。按作业班组分组被认为适合用于研究当前粉尘暴露与呼吸效应之间的关联。根据作业班组中估算的工人特定平均暴露量,参与研究流行病学部分的299名工人的算术平均累积暴露量,可吸入粉尘为38.1 mg·yr/m³,石英为2.0 mg·yr/m³。