孕酮预防早产：美国母胎医学专科认证专家的实践模式
Progesterone for preventing premature birth: practice patterns of board-certified maternal-fetal medicine specialists in the United States.
作者信息
Ness Amen, Baxter Jason, Hyslop Terry, Berghella Vincenzo
机构信息
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, and Biostatistics Section, Jefferson Medical College of Thomas Jefferson University, 834 Chestnut Street, Suite 400, Philadelphia, PA 19107, USA.
出版信息
J Reprod Med. 2006 May;51(5):411-5.
OBJECTIVE
To determine the current prescription of progesterone to prevent preterm birth (PTB) among board-certified maternal-fetal medicine (MFM) specialists in the United States.
STUDY DESIGN
A survey of the board-certified MFM specialists in the United States examining their prescription of and attitudes regarding progesterone to prevent PTB 6 months following publication of a National Institute for Child Health and Human Development trial.
RESULTS
Of 1,264 questionnaires sent, 526 were returned (response rate, 42%). After exclusions, 522 surveys remained. One hundred ninety-eight (38%) respondents prescribed progesterone, and 324 (62%) did not. Most nonprescribers were awaiting more data and were more concerned than prescribers about long-term effects (p < 0.0001). Twenty percent of prescribers prescribed progesterone for women with current signs or symptoms of preterm labor.
CONCLUSION
As a result of recent evidence, over one third of MFM specialists surveyed have begun prescribing progesterone to prevent PTB. Of these specialists, 20% are using it for indications other than a prior PTB.
目的
确定美国获得认证的母胎医学（MFM）专家预防早产（PTB）时孕酮的当前处方情况。
研究设计
对美国获得认证的MFM专家进行一项调查，考察在国立儿童健康与人类发展研究所的一项试验发表6个月后，他们预防PTB时孕酮的处方情况及态度。
结果
共发送1264份问卷，526份被返还（回复率42%）。排除无效问卷后，剩余522份调查问卷。198名（38%）受访者开具孕酮处方，324名（62%）未开具。大多数不开具处方者在等待更多数据，且比开具处方者更担心长期影响（p<0.0001）。20%的开具处方者为有早产当前体征或症状的女性开具孕酮。
结论
基于近期证据，超过三分之一接受调查的MFM专家已开始开具孕酮预防PTB。在这些专家中，20%将其用于既往PTB以外的指征。
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