Ghazi Leyla, Ko Fred, Bathgate Susanne L, Larsen John W, Macri Charles
Department of Obstetrics and Gynecology, George Washington University School of Medicine, 2150 Pennsylvania Avenue, NW, Washington, DC 20037, USA.
J Reprod Med. 2006 May;51(5):431-4.
Sacrococcygeal teratoma, the most common congenital neoplasm of the newborn, associated with fetal hydrops and high morbidity and mortality related to the secondary effects of the tumor mass, is of unknown etiology. Prompt diagnosis and early treatment have proven to be effective.
A 24-year-old woman, gravida 3, para 2, at 385/7 weeks' gestation, with a pregnancy complicated by HIV diagnosed during pregnancy, seizure disorder and tobacco use, presented with premature rupture of membranes. Ultrasound examination at 17 weeks' gestation showed normal fetal anatomy. Cesarean delivery was complicated by difficulty delivering a live infant with a large sacral mass. Successful surgical excision of a 650-g mass and stabilization of the infant occurred in the neonatal period.
This is the first case report to describe a rapidly growing sacrococcygeal teratoma in a neonate from a pregnancy complicated by HIV. Ultrasound in the first and second trimesters identified no fetal abnormalities of the spine. Further research concerning sacrococcygeal teratoma and HIV in pregnancy is necessary for prompt and early diagnosis and treatment of antepartum and peripartum complications.
骶尾部畸胎瘤是新生儿最常见的先天性肿瘤，与胎儿水肿以及因肿瘤肿块的继发效应导致的高发病率和死亡率相关，其病因不明。已证实及时诊断和早期治疗是有效的。
一名24岁女性，孕3产2，妊娠38⁵/₇周，孕期合并人类免疫缺陷病毒（HIV）感染、癫痫症且有吸烟史，胎膜早破。孕17周时超声检查显示胎儿解剖结构正常。剖宫产时娩出一名伴有巨大骶部肿块的活婴困难。新生儿期成功手术切除了一个650克的肿块并使婴儿情况稳定。
这是首例描述妊娠合并HIV的新生儿中快速生长的骶尾部畸胎瘤的病例报告。孕早期和孕中期超声检查未发现胎儿脊柱异常。对于产前和围产期并发症的及时和早期诊断与治疗，有必要对妊娠合并骶尾部畸胎瘤和HIV进行进一步研究。
