Winhammar J M C, Joffe D, Simmul R, Schoeffel R, Kiernan M C, Rowe D B
Department of Neurology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Intern Med J. 2006 Jul;36(7):419-22. doi: 10.1111/j.1445-5994.2006.01102.x.
With increasing awareness of motor neuron disease (MND) in Australia, the approach to respiratory management of patients with this disease will more commonly face the respiratory physician.
The aim of this study was to determine if standard respiratory function tests could determine the presence of nocturnal hypoxia (NH) in patients with MND.
Respiratory function tests were used to examine daytime respiratory function, and sleep studies were used to detect NH in 16 consecutive patients with MND and in 9 healthy control subjects. Demographic data, clinical parameters, respiratory function tests and sleep studies were obtained. Statistical analyses were carried out using t-tests and anova, where appropriate.
NH was detected in 50% of patients with MND, with no hypoxic events detected in the control group. Standard respiratory function tests were not able to predict the presence of NH.
There was no correlation between respiratory function tests and NH. This study emphasizes the inability of standard respiratory function tests to predict NH that may arise early in the course of MND.
随着澳大利亚对运动神经元病（MND）的认识不断提高，患有这种疾病的患者的呼吸管理方法将更频繁地摆在呼吸内科医生面前。
本研究的目的是确定标准呼吸功能测试能否确定MND患者夜间低氧血症（NH）的存在。
使用呼吸功能测试来检查白天的呼吸功能，并使用睡眠研究来检测16例连续的MND患者和9名健康对照者的NH。获取了人口统计学数据、临床参数、呼吸功能测试和睡眠研究结果。在适当的情况下，使用t检验和方差分析进行统计分析。
在50%的MND患者中检测到NH，对照组未检测到低氧事件。标准呼吸功能测试无法预测NH的存在。
呼吸功能测试与NH之间没有相关性。本研究强调标准呼吸功能测试无法预测MND病程早期可能出现的NH。
